Performance and Feasibility of Therapeutic Vibrating Mesh Nebulizer for Ventilation Lung Scan

This study aimed to evaluate the performance of a therapeutic vibrating mesh-type nebulizer for pulmonary delivery radioaerosols lung scintigraphy in healthy subjects. Six subjects (mean age 28.7 ± 6.2 years) inhaled 2 mL Tc-99m diethylenetriaminepentaacetic acid and normal saline solution (20 mCi) via (DK010, DELBio, Taipei, Taiwan). The nebulizer’s mass median aerodynamic diameter was between 2.3 5.0 µm (3.47 0.37 µm), nebulization rate greater than 0.2 mL/min. Scintigraphy performed count regions interest determine total regional deposition extrathoracic airway aerosols, penetration radioactivity balance (RCB). depositions aerosols were 21.2% 5.2% (% ex-valve dose), 27.4% 8.0% ex-device 13.8% 4.1% initial dose) nebulizer. 4.8% 1.1%. RCB 5.4% 3.0%. ratio outer over inner (O/I ratio, or index) 1.89 0.55. efficiency peripheral lung, which achieved by DELBio DK010 nebulizer, similar commercialized jet-type nebulizers dedicated radioaerosol (DELBio DK010) is feasible radionuclide ventilation scintigraphy.